Brown Fat Diabetes Cooling Study of Cold Acclimation Shows Profound Increase in Insulin Sensitivity in Only 10 Days
A recent study of brown fat diabetes evaluating the promise of cooling as a therapy for people with type 2 diabetes published on nature.com added to mounting evidence of major benefits. People with type 2 diabetes participating in the study of brown fat cooling showed better improvement in their insulin sensitivity than seen in the currently most recommended therapy of long term exercise for diabetes. “Insulin sensitivity was markedly increased after cold acclimation as indicated by on average a 43% increase in the glucose infusion rate….”
After just 10 days of cold acclimation people in the study with type 2 diabetes showed very significant positive impact on both whole-body and skeletal muscle sensitivity to insulin. As a result glucose uptake is markedly improved leading the researchers to conclude that brown fat cooling is a valid new way to improve the metabolic health of people with diabetes.
The method of cold acclimation to study the area of brown fat diabetes cooling therapy was remarkably simple and short. Eight overweight males were included in the study which originally was intended to include eleven to obtain valid results. During the study of the initial eight subjects the results on insulin sensitivity from cold acclimation of brown adipose tissue (brown fat) were so significant that the study was shortened with the approval of an external research monitoring board. During the ten day cold acclimation test, the study subjects were in a room kept at 14-15 degrees centigrade with exposure times increased starting with 2 hours on day 1, 4 hours on day 2, and 6 hours on days 3-10. Patients in the study used their normal medications for type 2 diabetes, ate standardized meals at the same time and were told not to exercise.
Exciting opportunities for brown fat diabetes cooling therapies are opened up by this key study, with a cooling vest for brown fat weight loss and diabetes treatment being one that is convenient. The combination of both brown fat cooling and exercise for diabetes treatment is another exciting concept: one that Dr. George King, head of research at Joslin Diabetes Center is already exploring at the Harvard Medical School institution’s headquarters where a “Joslin Coolout” workout in a cool room has started.