Tag Archives: brown fat obesity

6 Brown Fat Cell Areas In your Body: Key for Brown Fat Diabetes and Obesity Therapies

Study Creates Detailed Map of Brown Adipose Tissue Deposits

More accurate research on importance of brown fat activation now possible.

Cool Fat Burner

6 Brown Adipose Tissue Depots

Many studies have shown that increasing the activity of brown fat or BAT in humans will burn calories for weight loss and improve the body’s sensitivity to insulin improving health for those with diabetes. The exact location and size of BAT deposits has been hard to measure. “Normal” BAT locations and volume has not been precisely studied. 

Brown fat is an important area of research for the treatment of obesity and diabetes now that research has shown that it burns calories after exposure to cold. Glucose is used up by brown fat to maintain internal body temperature instead of becoming stored as white belly fat for future use. Because BAT cells are distributed or mixed-in with white fat cells, muscle, and blood vessels, it has proven very difficult to get accurate measurements. 

In the published study “Mapping of human brown adipose tissue in lean and obese young men,”1) scientist have refined the method of using PET/CT imaging for locating brown fat in humans and estimating its ability to burn calories. People in the study were exposed to cold in a room for 5 hours a day. On the last day before measurement they were kept at the lowest temperature they could tolerate before shivering: around 16 degrees centigrade.1) What researchers did was identify 6 areas of importance in the body where brown adipose tissue is located. They also were able to measure the metabolic capacity of the brown fat in those areas to better understand its role and importance. 

The key BAT discovery? We have much more brown fat in our bodies than we thought. Most people never use this belly fat burning tissue to its full potential. How much calorie burn could be gained? An estimate is that brown fat cold exposure would increase  daily calorie burn by greater than 520 calories. The authors conclude “…that if BAT could be maximized to its volumetric and metabolic capacity, it would substantially affect energy metabolism in adult humans.”1)

How do you increase your BAT activity for your health? Increasing cold exposure and getting outside are at the top of the list. Cold exposure using a cooling vest for brown fat is the simplest way to stimulate your brown adipose tissue, and liquid cooling suits have been used in many studies as well as cold rooms.

Your thoughts and comments are welcome. Would you let us know what you think?

1)Shivering, which is uncomfortable, also is a different way the body tries to stay warm. “Non-shivering thermogenesis” is the role BAT plays in keeping us warm. Cool burn or coolsculpting methods literally freeze the tissue, do not focus on brown fat activation for long term metabolic health, and can be dangerous.

1)PNAS, August 8, 2017, vol. 114, no. 32, p 8653

1)PNAS, August 8, 2017, vol. 114, no. 32, pp. 8649-8654 with full text of this brown fat study available for free online

Diabetes Epidemic Grows as Global Temperatures Rise

Global Warming Linked to Diabetes Epidemic: Reduction in Brown Fat Activity Blamed in Study

Significant increases in glucose intolerance leading to a diabetes epidemic is correlated to global warming according to a new research paper. Global warming causing decreased brown adipose tissue activity is leading to increasing cases of diabetes: a metabolic disease that results from the body becoming glucose intolerant.1)

Analyzing years of worldwide data showing climate change and the number of diabetes cases, scientists have seen a strong link between the number of cases of diabetes diagnosed each time average temperatures increased by 1 degree. Based on prior studies of brown fat activation showing exposure to mild cold is a potential therapy for diabetes, researchers concluded that: “[O]ur data are consistent with the hypothesis that a decrease in BAT activity with increas- ing environmental temperature may deteriorate glucose metabolism and increase the incidence of diabetes.”

Obesity, a factor in the cause of type 2 diabetes,  also rose in relation to increases in temperature with a 0.173% increase in obesity cases with each single degree of temperature increase. Diabetes, related to the body’s increased resistance to insulin, grew by 3.1% per 10,000 people each time the climate warmed by 1 degree celsius. Data was drawn from sources covering the years 1996 through 2013. 

diabetes epidemic, cooling vest weight loss

Mean annual temperature and diabetes cases per degree of temperature increase by state.

Just published this week, the detailed study is getting major media attention as the world struggles with the major health challenge of the diabetes epidemic and rise in obesity with all kinds of bad implications for metabolic health. Newsweek has provided the best easy to read summary of the research paper.

Solutions are coming to market. Hyperwear has patented a cooling vest that can be worn to activate brown fat using mild cold that is comfortable and part of a solution for better health and weight loss.

1) Blauw LL, Aziz NA, Tannemaat MR, et al. Diabetes incidence and glucose intolerance prevalence increase with higher outdoor temperature. BMJ Open Diabetes Research and Care 2017;5:e000317. doi:10.1136/bmjdrc-2016- 000317

Weight Loss Vest: Top 5 Facts

Top 5 Facts About Weight Loss Vest Research

What studies say about cooling vests and brown fat weight loss

COMMENTARY

A brown fat weight loss vest must use mild cold

A weight loss vest cooling vest using ice packs or any cooling packs cold enough to trigger shivering are not going to properly activate brown fat to increase your metabolism and burn more calories. Brown adipose tissue uses a process called “non-shivering thermogenesis.” Non-shivering thermogenesis is the body’s natural response to mild cold. Very cold temperatures cause shivering which is a short-term and entirely different reaction by the body where rapid muscle contractions generate heat. The point where your body’s response shifts from non-shivering to shivering thermogenesis varies by individual, but is around 58 degrees Fahrenheit. Cooling vests for brown fat weight loss should not use ice cold cooling packs of thirty degrees Fahrenheit. Ice cold cooling vests and packs also create a danger of skin damage and burns from freezing. Activation of brown fat using non-shivering thermogenesis is best with special phase change material (PCM) cooling packs that can be designed to have a melting point at or around 60 degrees Fahrenheit.

A weight loss vest should cover more body surface area

Using a cooling vest for brown adipose tissue stimulation is simply a more practical solution for what you can accomplish either by being outside in mild cold temperatures or being in a mild cold room kept at or around 60 degrees Fahrenheit. Naturally the more surface area that a cooling vest covers on the body the more closely it simulates being in a cold environment. Check the size of the cooling packs that are held by any weight loss cooling vest product. Calculate the total area the cooling packs will cover to compare how effective the cooling vest may be for brown fat activation.

thin ice vest

Cool fat burner: use a cold room?

 Brown fat cooling packs should be designed to make full body contact

How does a cooling vest work? Cooling packs against your body act like a heat sink. There is a thermal exchange between your body and the cooling pack. While the cooling pack is colder than your body it draws heat away from your body and cools your body. So the more direct body contact made by your cooling pack, the better the performance. Ideally, flexible cooling packs with a flat surface are used that conform to the body and are held in place by a well designed vest using compression to hold the packs firmly to the body.

A longer lasting weight loss vest is better

Studies of brown fat cooling have all used mild cold exposure but for varying lengths of time and temperature. Cooling vests that have been used for scientific research to date have been chilled water circulation vests that require connection by tubes to a chiller. Time periods for the water circulation vests have been no more than a couple of hours. So the longer a cooling pack stays cold in a cooling vest for brown fat, the longer your cold exposure and logically the effectiveness. A cooling vest designed to allow easy removal of warm packs and replacement with cold spares can allow extended mild cold exposure.

A weight loss vest for brown fat should be designed for comfort and exercise

Of all considerations, comfort and freedom of movement for exercise and long wear time is key to gaining the benefits of brown fat cooling. Encouraging regular use and convenience is essential. While no studies have explored the combination of exercise and cooling to date, having an athletic cooling vest design to allow exercise in the cold should provide the most effective health benefit. The key is to hold the cooling packs tight to your body and keeping them from bouncing and moving during exercise.

While these are the five key factors in purchasing a cooling product for brown fat health benefits, keep in mind others are important such as: style, fit, quality, warranty, and value for your money.  Do your own research about what makes a real product that is a true cool fat burner and study the truth about freezing your fat off.

cool fat burner weight loss vest

Lose fat with fat

Question or comment?

Brown Fat Diabetes Fighting Organ ?

Brown Fat Diabetes Research Published

Researchers find that brown fat is an anti-diabetes organ

Brown Fat Diabetes

Diabetes may be treated by stimulating brown fat

Not all fat is created equal, and that is good news for millions fighting diabetes. In a study of the metabolic role of brown fat diabetes researchers at the University of Texas Medical Branch at Galveston showed that people with more brown fat are able to maintain control over their blood sugar and increase their resting metabolic rate. 1)Chondronikola M. Brown Adipose Tissue Improves Glucose Metabolism and Whole Body Insulin Sensitivity in Humans. Scientific Session of the American Diabetes Association, San Francisco, June 2014.

How did they do it? The study, led by Dr. Labros Sidossis,  included adult male subjects who were divided into two groups: one group had brown fat present at the start of the study and the other did not. All subjects wore a cooling vest for several hours at a mild cold temperature that would stimulate brown fat and not cause a shivering response.

The results showed that active brown fat plays an important role in metabolism of glucose. People in the study who had stores of brown fat that were activated by the cooling vest were better able to metabolize glucose and had increased insulin sensitivity. The abstract of the study states:

“These results demonstrate a physiologically significant role of BAT in whole-body energy expenditure, glucose homeostasis, and insulin sensitivity in humans and support the notion that BAT may function as an anti-diabetic tissue in humans.”

Researchers found that mild cold exposure increased the base metabolic rate of the brown fat positive group by 15%. Very significant reductions in blood glucose were seen in the individuals with cold stimulated brown fat.

While some studies have lowered thermostats in a room to create mild cold conditions, this is the third study to use a liquid circulating cooling vest or garment connected by tubing to a chiller.2)Blondin, Increased brown adipose tissue oxidative capacity in cold-acclimated humans, J Clin Endocrinol Metab doi:10.1210/jc.2013-3901 1)(Cypess, Cold but not sympathomimetics activates human brown adipose tissue in vivo, PNAS June 19, 2012, vol. 109, no. 25.  While effective, using a brown fat cooling vest that keeps you connected to a chiller by tubes requires the person to remain still and is not practical for real world use. The water cooled vests are very expensive devices used by surgeons to remain cool during long procedures. Cooling is acknowledged as the best know way to stimulate brown fat, but researchers are mainly focused on finding a drug as a treatment for obesity and diabetes. Cooling vests with phase change cooling packs to activate brown adipose tissue may provide the best solution.

 

 

 

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